Promethazine is an antihistamine drug, and of course it has a number of contraindications. Before you start taking any medication, be sure to familiarize yourself with the side effects. And decide whether it is worth taking it.
Hypersensitivity (including to other phenothiazines), concomitant use of MAO inhibitors, lactation, early childhood (under 3 months).
Caution. Bladder neck obstruction, prostatic hypertrophy with clinical manifestations, predisposition to urinary retention, epilepsy, open-angle or closed-angle glaucoma, coma, liver failure, Jaundice, bone marrow dysfunction, diseases of the CSS (severe angina, arterial hypertension, decompensated CHF, atrial fibrillation), Reye syndrome, pregnancy, children (under 2 years) and elderly.
Nervous system disorders: sedative effect, dizziness, somnolence, anxiety, psychomotor agitation, “nightmares” dreams, increased nighttime apnea; rarely – disorientation, confusion, extrapyramidal disorders, increased seizure activity (in children).
Sensory organs: accommodation and vision disorders, tinnitus or ringing in the ears.
Cardiovascular system: orthostatic hypotension (when injected intravenously), decreased blood pressure, tachycardia or bradycardia.
Digestive system: anesthesia of the oral mucosa, dry mouth (when administered orally), nausea, vomiting, cholestasis, constipation.
Respiratory system: dryness in the nose and pharynx. Urinary system: rarely – difficult or painful urination.
Laboratory parameters: rarely – leukopenia, thrombocytopenia, agranulocytosis.
Allergic reactions: urticaria, dermatitis, asthma. Local reactions: when administered intramuscularly – painful infiltration at the injection site. Others: increased sweating, photosensitization.
Overdose. Symptoms: in children – agitation, anxiety, hallucinations, ataxia, athetosis, convulsions, mydriasis and fixed pupils, facial hyperemia, hyperthermia; then – vascular collapse, coma; in adults – lethargy, depression, coma; then – psychomotor agitation, convulsions.
Treatment: gastric lavage, oral administration of activated charcoal (when detoxifying early after oral administration of the drug); antiepileptic drugs, IVH and other resuscitation measures are indicated, dialysis is ineffective.
Increases the effect of narcotic analgesics, hypnotics, anxiolytics (tranquilizers) and antipsychotic drugs (neuroleptics), as well as drugs for general anesthesia, local anesthetics, m-cholinoblockers and hypotensive drugs (requires dose adjustment). It reduces the effect of amphetamine derivatives, m-cholinostimulants, anticholinesterase drugs, ephedrine, guanethidine, levodopa, dopamine. Barbiturates accelerate elimination and decrease activity. Beta-adrenoblockers increase (mutually) plasma concentrations (pronounced BP decrease, arrhythmias, irreversible retinopathy, tardive dyskinesia are possible).
It weakens the effect of bromocriptine and increases the serum concentration of prolactin.
Tricyclic antidepressants and anticholinergic drugs increase m-cholinoblocking activity, ethanol, clopheline, antiepileptic drugs – CNS depression.
MAO inhibitors (concomitant use is not recommended) and phenothiazine derivatives increase the risk of arterial hypotension and extrapyramidal disorders. Quinidine increases the likelihood of cardiodepressive effects. Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.